| Abstrakt: |
Comparative study of cellular-tissue reactions in the endocrine organs (thyroid and adrenal glands and ovary) of rodents exposed to radiation under natural conditions (Radium station in the Komi Republic and 30-km zone of Chernobyl NPP) and under experimental conditions modeling chronic exposure is carried out. Evidence is found that low-dose chronic irradiation causes morphological disorders at different levels of structural organization (cellular-tissue, organism, and population levels). The experimental results show that the observed variations in the morphometric parameters of the thyroid and adrenal glands and ovary reflect natural changes in their functional activity (within the physiological limits). These changes are directed at the maintenance of homeostasis under altered conditions and have a compensatory and adaptive character. The effects of low-dose radiation in combination with other agents may be amplified at the level of cellular-tissue reactions. In comparison with the experimental results, natural conditions (high level of radioactivity due to α and β emitters, high natural radionuclides, toxic elements, and extreme climatic factors) induce more pronounced changes, including a significant increase in chromosomal and gene mutations in cells, destructive processes in the organs of the endocrine system, and disorders of reproductive functions. [ABSTRACT FROM AUTHOR] |
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