A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer.

Autor: Williams, Marion L., Bhargava, Pankaj, Cherrouk, Ilham, Marshall, John L., Flockhart, David A., Wainer, Irving W.
Předmět:
Zdroj: British Journal of Clinical Pharmacology; May2000, Vol. 49 Issue 5, p485, 4p
Abstrakt: Examines the relationship between cytochrome P450 2C19 genotype and expressed metabolic activity in patients with advanced cancer. Impact of a decrease in expressed enzyme activity on the efficacy and toxicity of chemotherapeutic agents and other drugs used in oncology practice; Restriction fragment length analysis.
Databáze: Complementary Index