| Autor: |
Doebis, Cornelia, Menning, Astrid, Neumann, Katrin, Ghani, Saeed, Schlawe, Kerstin, Lauer, Uta, Hamann, Alf, Huehn, Jochen, Syrbe, Uta |
| Předmět: |
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| Zdroj: |
Immunology & Cell Biology; May/Jun2011, Vol. 89 Issue 4, p566-572, 7p, 4 Graphs |
| Abstrakt: |
Although activation and subsequent expansion of naive CD4+ T cells within lymph nodes is well characterized, the fate of T effector cells activated within peripheral tissues during secondary reactions is poorly defined. Therefore, we studied the recruitment, proliferation and egress of antigen-specific Th1 effector cells in comparison with nonspecific Th1 cells throughout a delayed-type hypersensitivity reaction (DTH). Although we observed a high turnover of Th1 effector cells with unspecific high-rate recruitment and CCR7-dependent egress from the inflamed tissue in the early, acute DTH phase, a strong, selective accumulation of antigen-specific T cells occurred during the chronic, late DTH phase. This was mainly based on local proliferation of CD4+ effector cells within the DTH tissue and concomitant retention. Considering the strong CCR7-dependent Th cell egress found in this model, the reduced CCR7 expression on antigen-specific T cells isolated from late-phase DTH tissue most likely contributes to the retention of these cells within the tissue. Thus, peripheral tissues can support not only the proliferation of CD8+ T cells, as recently shown, but also that of CD4+ T effector cells, forming a pool of tissue-resident T cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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