| Autor: |
Rojas, Santiago, Herance, José Raul, Abad, Sergio, Jiménez, Xavier, Pareto, Deborah, Ruiz, Alba, Torrent, Èlia, Figueiras, Francisca P., Popota, Foteini, Fernández-Soriano, Francisco J., Planas, Anna M., Gispert, Juan D., Herance, José Raul, Jiménez, Xavier, Torrent, Èlia, Fernández-Soriano, Francisco J, Torrent, Elia |
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| Zdroj: |
Molecular Imaging & Biology; Jun2011, Vol. 13 Issue 3, p558-564, 7p, 3 Diagrams, 1 Graph |
| Abstrakt: |
Purpose: [¹⁸F]Fluoromisonidazole (¹⁸F-FMISO) is a nitroimidazole derivative that has been proposed as a positron emission tomography (PET) radiotracer to detect hypoxic tissue in vivo. This compound accumulates in hypoxic but viable tissue and may be a good candidate for evaluating the ischemic penumbra. We evaluated the time course of ¹⁸F-FMISO uptake using PET in a rat model of permanent cerebral ischemia and the correlation with histological changes.Procedures: Rats (n = 14) were subjected to permanent ischemia by intraluminal occlusion of the middle cerebral artery in order to assess by PET the uptake of ¹⁸F-FMISO at various times over 24 h following ischemia. The PET results were compared to histological changes with Nissl and 2,3,5 triphenyltetrazolium chloride staining.Results: Elevated uptake of ¹⁸F-FMISO was detected in the infarcted area up to 8 h after occlusion but was no longer detected at 24 h, a time point coincident with pan necrosis of the tissue.Conclusions: Our findings suggest that salvageable tissue persists for up to 8 h in this rat model of brain ischemia. We propose ¹⁸F-FMISO PET as a tool for evaluating the ischemic penumbra after cerebral ischemia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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