Synthesis, chemical properties, and antimicrobial activity of 2- and 2,3-substituted [(tetrahydro-2,4-dioxopyrimidin-1(2 H)-yl)phenoxy]naphthalene-1,4-diones.

Autor: Voskienė, Aušra, Sapijanskaitė, Birutė, Mickevičius, Vytautas, Kantminienė, Kristina, Stasevych, Maryna, Komarovska-Porokhnyavets, Olena, Musyanovych, Rostyslav, Novikov, Volodymyr
Zdroj: Chemical Monthly / Monatshefte für Chemie; May2011, Vol. 142 Issue 5, p529-537, 9p, 2 Diagrams, 3 Charts
Abstrakt: Mono- and disubstituted [(tetrahydro-2,4-dioxopyrimidin-1(2 H)-yl)phenoxy]naphthalene-1,4-diones were synthesized by the reaction of dihydro-1-(3-hydroxy- and 4-hydroxyphenyl)pyrimidine-2,4(1 H,3 H)-diones and their 5- and 6-methyl derivatives with 2,3-dichloro-1,4-naphthoquinone. Their stability in alkaline and acidic media was investigated. Four of the compounds exhibited good antimicrobial activity against Staphylococcus aureus, Mycobacterium luteum, Candida tenuis, and Aspergillus niger. Graphical abstract: [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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