| Autor: |
Steiger, Howard, Gauvin, Lise, Israël, Mimi, Koerner, Naomi, Ng Ying Kin, N. M. K., Paris, Joel, Young, Simon N. |
| Předmět: |
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| Zdroj: |
Archives of General Psychiatry; Sep2001, Vol. 58 Issue 9, p837, 7p |
| Abstrakt: |
Background: Bulimia nervosa (BN) is reported to co-occur with childhood abuse and alterations in central serotonin (5-hydroxytryptamine [5-HT]) and cortisol mechanisms. However, findings also link childhood abuse to anomalous 5-HT and cortisol function, and this motivated us to explore relationships between childhood abuse and neurobiological variations in BN. Methods: Thirty-five bulimic and 25 nonbulimic women were assessed for childhood physical and sexual abuse, eating symptoms, and comorbid psychopathological tendencies. These women provided blood samples for measurement of platelet hydrogen-3–paroxetine binding and serial prolactin and cortisol responses following oral administration of the partial 5-HT agonist meta-chlorophenylpiperazine (m-CPP). Results: Bulimic women showed markedly lower mean ± SD density (B[sub max]) of paroxetine-binding sites (631.12 ± 341.58) than did normal eaters (1213.00 ± 628.74) (t[sub 54] = -4.47; P = .001). Paroxetine binding did not vary with childhood abuse. In contrast, measures of peak change on prolactin levels after m-CPP administration (Δ-peak prolactin) indicated blunted response in abused bulimic women (7.26 ± 7.06), nonabused bulimic women (5.62 ± 3.95), and abused women who were normal eaters (5.73 ± 5.19) compared with nonabused women who were normal eaters (13.57 ± 9.94) (F[sub 3,51] = 3.04, P = .04). Furthermore, individuals reporting childhood abuse showed decreased plasma cortisol levels relative to nonabused women who were normal eaters. Conclusion: Findings imply that BN and childhood abuse are both generally associated with reduced 5-HT tone but that childhood abuse may be somewhat more specifically linked to reduced cortisol levels (ie, hypothalamic-pituitary-adrenal axis) activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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