| Autor: |
Gherghel, Doina, Orgül, Selim, Dubler, Barbara, Lübeck, Patricia, Gugleta, Konstantin, Flammer, Josef |
| Předmět: |
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| Zdroj: |
Archives of Ophthalmology; Oct99, Vol. 117 Issue 10, p1359, 4p |
| Abstrakt: |
Objective: To assess the relation between ocular perfusion pressure and blood flow velocity in the central retinal artery in patients with acral vasospasm. Subjects and Methods: Eighteen otherwise healthy subjects with acral vascular dysregulation, as demonstrated by nail-fold capillaroscopy, and 18 age- and sex-matched healthy volunteers without vasospasm were recruited. After subjects had rested for 20 minutes in a supine position, intraocular pressure and blood flow velocity in the central retinal artery were determined by applanation tonometry and color Doppler imaging, respectively. The peak systolic velocity, end-diastolic velocity, and resistivity index were assessed. Correlations between the mean ocular perfusion pressure (2/3×[2/3× diastolic blood pressure+1/3×systolic blood pressure]-intraocular pressure) and blood flow velocities in the central retinal artery were determined by the Pearson linear correlation factor. The Student t test was used to evaluate differences between controls and subjects with vasospasm. Results: The mean±SD ocular perfusion pressure was 42.0±7.4 mm Hg in the group with vasospasm and 47.1±6.5 mm Hg in the control group (P=.04). In the subjects with vasospasm, the peak systolic and end-diastolic velocities and the resistivity index of the central retinal artery correlated significantly with the mean ocular perfusion pressure (R=0.49, P=.04; R=0.58, P=.01; and R=-0.67, P=.002, respectively). Such correlations were not found in the control group. Conclusion: An altered blood flow regulation is suggested in the ocular circulation of patients with acral vasospasm. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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