| Autor: |
Bhattacherjee, Parimal, Paterson, Christopher A., Spellman, Joan M., Graff, G., Yanni, John M. |
| Předmět: |
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| Zdroj: |
Archives of Ophthalmology; Mar1999, Vol. 117 Issue 3, p361, 4p |
| Abstrakt: |
Objective: To validate pharmacologically the feline model of steroid-induced ocular hypertension. Methods: Serial studies were conducted in domesticated adult female cats trained to accept topical ocular drug administration and pneumotonometry. To establish intraocular pressure (IOP) values for each study, measurements were performed at the same time of day for 6 consecutive days. Beginning on day 7, cats received either steroid or vehicle administered topically to both eyes three times a day for approximately 28 days. The IOP measurements were performed daily. Results: After 5 to 7 days of treatment with 0.1% dexamethasone or 1.0% prednisolone acetate, lap began to increase, reaching peak values within 2 weeks. These values were sustained throughout dosing but declined rapidly to baseline upon cessation of treatment. Maximum laps for the dexamethasone- and prednisolone-treated groups averaged 4.5 ± 0.3 mm Hg (n = 12) greater than the mean lap value obtained in vehicle-treated cats. Cawere significantly lower than those observed following treatment with dexamethasone or prednisolone. Conclusions: The ocular hypertensive effects of selected anti-inflammatory topical ocular steroids in this model are consistent with clinical findings. Clinical Relevance: This feline model is a useful tool for assessing the potential lOP liability of novel antiinflammatory steroids. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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