| Autor: |
Tezel, Gülgün, Siegmund, Kim D., Trinkaus, Kathryn, Wax, Martin B., Kass, Michael A., Kolker, Allan E. |
| Předmět: |
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| Zdroj: |
Archives of Ophthalmology; Jun2001, Vol. 119 Issue 6, p813, 6p |
| Abstrakt: |
Background: Reducing intraocular pressure (lOP) in glaucomatous eyes does not always prevent disease progression. Objective: To determine the clinical factors associated with progressive optic disc damage in glaucomatous eyes receiving treatment to reduce IOP. Methods: Baseline and follow-up optic disc photographs as well as demographic and clinical data were retrospectively studied in 186 eyes of 93 patients with primary open-angle glaucoma, and in 138 eyes of 69 patients with normal-pressure glaucoma. The patients with primary open-angle glaucoma were included in the study only if their treated lOPs during a follow-up period of 5 years were less than 21 mm Hg. The patients with normalpressure glaucoma were included only if their IOPs were reduced by at least 20% during the follow-up period. The association of progressive optic disc damage with patient- and eye-specific characteristics was examined using multivariate analysis. Results: During the 5-year study period, 141 (43.5%) of the 324 eyes exhibited progressive optic disc damage defined by at least a 5% decrease in the neural rim areato-disc area ratio. Using multivariate analysis, the following were found to be strongly associated with progressive neural rim damage: a baseline smaller neural rim area-disc area ratio (P<.001); a baseline larger zone β area-disc area ratio (P=.04); a baseline larger parapapillary atrophy length-disc circumference ratio (P=.05); a diagnosis of normal-pressure glaucoma (P=.01); and combined medical and surgical treatment prior to the study period (P=.01). Conclusions: Clinical factors other than IOP may be important indicators of subsequent progression of glaucomatous optic disc damage. Our findings suggest that eyes with advanced glaucomatous optic disc damage and normal-pressure glaucoma are more likely to progress despite receiving treatment to reduce IOP. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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