| Autor: |
Haley, Robert W., Fleckenstein, James L., Marshall, W. Wesley, McDonald, George G., Kramer, Gerald L., Petty, Frederick |
| Předmět: |
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| Zdroj: |
Archives of Neurology; Sep2000, Vol. 57 Issue 9, p1280, 6p |
| Abstrakt: |
Background: Many complaints of Gulf War veterans are compatible with a neurologic illness involving the basal ganglia. Methods: In 12 veterans with Haley Gulf War syndrome 2 and in 15 healthy control veterans of similar age, sex, and educational level, we assessed functioning neuronal mass in both basal ganglia by measuring the ratio of N-acetyl-aspartate to creatine with proton magnetic resonance spectroscopy. Central dopamine activity was assessed by measuring the ratio of plasma homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenlyglycol (MHPG). Results: The logarithm of the age-standardized HVA/MHPG ratio was inversely associated with functioning neuronal mass in the left basal ganglia (R[sup 2] = 0.56; F[sub 1,27] = 33.82; P<.001) but not with that in the right (R[sup 2] = 0.04; F[sub 1,26] = 1.09; P = .30). Controlling for age, renal clearances of creatinine and weak organic anions, handedness, and smoking did not substantially alter the associations. Conclusions: The reduction in functioning neuronal mass in the left basal ganglia of these veterans with Gulf War syndrome seems to have altered central dopamine production in a lateralized pattern. This finding supports the theory that Gulf War syndrome is a neurologic illness, in part related to injury to dopaminergic neurons in the basal ganglia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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