Chemical constituents from fermented broth and mycelium of the basidiomycete Lacrymaria velutina.

Autor: Yu-Ming Ju, Guei-Jane Wang, Chun-Yao Chen, Ya-Jing Tsau, Chang-Hung Chou, Tzong-Huei Lee
Předmět:
Zdroj: Botanical Studies; 2010, Vol. 51 Issue 3, p311-314, 4p
Abstrakt: Lacrymarone (1), a novel diterpenoid, together with seven known compounds 2-8 were isolated from the fermented broth and mycelium of Lacrymaria velutina, an edible fungus collected in Taiwan. The structures of 1-8 were elucidated by analyzing their spectroscopic data. Further biological tests revealed that the co-crystal of 7 and 8 exhibited a moderate inducible nitric oxide synthase (iNOS) inhibitory activity, and with an IC50 value of 59.54 ± 3.74 μM. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index