Mycobacterium tuberculosis phagosome.
| Autor: | Deretic, V, Fratti, R. A |
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| Zdroj: | Molecular Microbiology; Mar99, Vol. 31 Issue 6, p1603-1609, 7p, 1 Diagram, 1 Chart, 1 Graph |
| Abstrakt: | The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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