| Autor: |
Mnie-Filali, Ouissame, Faure, Céline, Lambás-Señas, Laura, Mansari, Mostafa El, Belblidia, Hassina, Gondard, Elise, Etiévant, Adeline, Scarna, Hélène, Didier, Anne, Berod, Anne, Blier, Pierre, Haddjeri, Nasser |
| Předmět: |
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| Zdroj: |
Neuropsychopharmacology; May2011, Vol. 36 Issue 6, p1275-1288, 14p, 7 Graphs |
| Abstrakt: |
Current antidepressants still display unsatisfactory efficacy and a delayed onset of therapeutic action. Here we show that the pharmacological blockade of serotonin 7 (5-HT7) receptors produced a faster antidepressant-like response than the commonly prescribed antidepressant fluoxetine. In the rat, the selective 5-HT7 receptor antagonist SB-269970 counteracted the anxiogenic-like effect of fluoxetine in the open field and exerted an antidepressant-like effect in the forced swim test. In vivo, 5-HT7 receptors negatively regulate the firing activity of dorsal raphe 5-HT neurons and become desensitized after long-term administration of fluoxetine. In contrast with fluoxetine, a 1-week treatment with SB-269970 did not alter 5-HT firing activity but desensitized cell body 5-HT autoreceptors, enhanced the hippocampal cell proliferation, and counteracted the depressive-like behavior in olfactory bulbectomized rats. Finally, unlike fluoxetine, early-life administration of SB-269970, did not induce anxious/depressive-like behaviors in adulthood. Together, these findings indicate that the 5-HT7 receptor antagonists may represent a new class of antidepressants with faster therapeutic action. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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