Marrow-Derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness.

Autor: Peyton, Shelly R., Kalcioglu, Z. Ilke, Cohen, Joshua C., Runkle, Anne P., Van Vliet, Krystyn J., Lauffenburger, Douglas A., Griffith, Linda G.
Předmět:
Zdroj: Biotechnology & Bioengineering; May2011, Vol. 108 Issue 5, p1181-1193, 13p, 1 Diagram, 5 Graphs
Abstrakt: The article discusses research concerning the motility of marrow-derived mesenchymal stem cells (MSC) in a three-dimensional (3D) scaffold geometrical structure. Details concerning cell culture preparation, polyethylene glycol (PEG) scaffold fabrication, and the examination of macroporous gels using scanning electron microscopy (SEM) are presented. The use of an inverse-opal processing technique in creating porous scaffolds is reported. The movement of MSC through the same 3D scaffolds is also quantified.
Databáze: Complementary Index