| Autor: |
Zhang, Dianfu, Zhang, Peliang, Wang, Yuguo, Cao, Shuren, Fang, Ruiyan, Liu, Yichang, Zhang, Tao |
| Zdroj: |
Chinese-German Journal of Clinical Oncology; Mar2011, Vol. 10 Issue 3, p144-146, 3p |
| Abstrakt: |
Objective: The aim of the study was to evaluate the therapeutic effect and safety of whole-course three-dimensional conformal radiotherapy (3DCRT) combined with late-course accelerated hyperfractionated radiotherapy (LCAFR) on patients with esophageal carcinoma. Methods: one hundred and one patients with esophageal carcinoma were divided into two groups. Observing group (49 cases) were treated by whole-course 3DCRT. Patients in control group (52 cases) were treated by conventional radiotherapy. Clinical efficiencies and radiation toxicities were compared between two groups. Results: The side effects including radiation esophagitis (63.2%) and tracheitis (49.0%) decreased in observing group, but there was no significant difference between two groups (69.2% and 55.7% in controls). The 1-, 2- and 3-year tumor local control rates and overall survival rates in the observing group were significantly improved compared with the control group, being respectively 87.8%, 75.5%, 63.3% vs 71.2%, 55.8%, 42.3% and 85.7%, 71.4%, 46.7% vs 69.2%, 51.9%, 26.9% (all P < 0.05). Conclusion: The therapeutic effect of whole-course 3DCRT combined with LCAFR for esophageal carcinomas is superior to conventional radiotherapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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