The study of DJ-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients.

Autor: Lisitskaya, K., Eremina, L., Ivanov, A., Kovalyova, M., Okhrits, V., Toropygin, I., Kovalyov, L., Shishkin, S.
Zdroj: Biochemistry (Biokhimiya). Supplemental Series B, Biomedical Chemistry; Mar2011, Vol. 5 Issue 1, p22-28, 7p
Abstrakt: Two electrophoretically distinguishable isoforms of Dj-1 protein have been identified in a proteomic study of tissue specimens obtained from patients with confirmed prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Dj-1 was also found in the cell lines PC-3, DU-145, LNCaP, BPH-1, and the lowest level of Dj-1 was found in BPH-1. An immunochemical study (ELISA) of serum levels of Dj-1, Bcl-2, IGF-1 and IGFBP-3 proteins revealed statistically significant differences between these two groups of patients only for Dj-1 ( p = 0.004, the Wilcoxon-Mann-Whitney test). These data suggest that Dj-1 protein is a perspective candidate biomarker for PCa. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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