The study of cytokine content and ganglioside metabolism in experimental brain edema.

Autor: Zakaryan, A., Kazaryan, G., Zakaryan, G., Melkonyan, M., Hovsepyan, L.
Zdroj: Biochemistry (Biokhimiya). Supplemental Series B, Biomedical Chemistry; Mar2011, Vol. 5 Issue 1, p51-54, 4p
Abstrakt: blood cytokine profile and also the brain content of lipid peroxidation (LPO) products and gangliosides were investigated in rats with experimental brain edema. The development of brain edema was accompanied by the increase in pro-inflammatory and a decrease in anti-inflammatory cytokine content. In parallel, accumulation of LPO products (conjugated dienes, hydroperoxides, and malondialdehyde) was observed. The study of ganglioside content under conditions of experimental brain edema revealed a decrease of their hydrolytic degradation product, sphingosine. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index