BID mediates neuronal cell death after oxygen/glucose deprivation and focal cerebral ischemia.

Autor: Plesnila, Nikolaus, Zinkel, Sandra, Le, Dean A., Amin-Hanjani, Sepideh, Yonqin Wu, Qiu, Jianhua, Chiarugi, Alberto, Thomas, Sunu S., Kohane, Daniel S., Korsmeyer, Stanley J., Moskowitz, Michael A.
Předmět:
Zdroj: Proceedings of the National Academy of Sciences of the United States of America; 12/18/2001, Vol. 98 Issue 26, p15318, 6p, 5 Black and White Photographs, 8 Diagrams, 4 Graphs
Abstrakt: Investigates the expression of BID, a proapoptotic promoter of cytochrome c release and caspase 8 substrate in brain. Activation of BID in the brain after an ischemic insult; Detection of BID in the cytosol of mouse brain; Contribution of BID and mitochondrial-amplification pathway to neuronal cell death.
Databáze: Complementary Index