| Autor: |
Sunil, P. M., Ramachandran, C. R., Devy, Santha, Varghese, Soma Susan |
| Předmět: |
|
| Zdroj: |
Oral & Maxillofacial Pathology Journal; Jan-Jun2011, Vol. 2 Issue 1, p89-95, 7p, 1 Color Photograph, 5 Diagrams, 1 Chart, 1 Graph |
| Abstrakt: |
Oral carcinogenesis is a multistep process in which multiple genetic events occurs that alter the normal functions of genes. Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumours in India. Many patients still die of the disease in spite of therapeutic procedures being improved. In our study 30 OSCC cases and 10 controls were studied by means of karyotyping using G-band technique, out of which 5 chromosomal abnormal patients were found, in which chromosome 18 deletion being prominent. It is also site specific, 4 out 5 patients with karyotype abnormalities had the tumour on buccal mucosa. It was also noted, most of patients with chromosomal abnormality were tobacco chewers, suggesting chemical carcinogens in tobacco has an impact on the chromosomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
