| Autor: |
Geppert, Ch., Blaum, K., Diel, S., Mu¨ller, P., Schreiber, W. G., Wendt, K. |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2001, Vol. 584 Issue 1, p249, 6p, 3 Diagrams, 3 Graphs |
| Abstrakt: |
Diode laser based multi-step resonance ionization mass spectrometry (RIMS), which has been developed primarily for ultra trace analysis of long lived radioactive isotopes has been adapted for the application to elements within the sequence of the rare earths. First investigations concern Gd isotopes. Here high suppression of isobars, as provided by RIMS, is mandatory. Using a three step resonant excitation scheme into an autoionizing state, which has been the subject of preparatory spectroscopic investigations, high efficiency of >1×10[sup -6] and good isobaric selectivity >10[sup 7] was realized. Additionally the linearity of the method has been demonstrated over six orders of magnitude. Avoiding contaminations from the Titanium-carrier foil resulted in a suppression of background of more than one order of magnitude and a correspondingly low detection limit of 4×10[sup 9] atoms, equivalent to lpg of Gd. The technique has been applied for trace determination of the Gd-content in animal tissue. Bio-medical micro samples were analyzed shortly after Gd-chelat, which is used as the primary contrast medium for magnetic resonance imaging (MRI) in biomedical investigations, has been injected. Correlated in-vivo magnetic resonance images have been taken. The RIMS measurements show high reproducibility as a well as good precision, and contribute to new insight into the distribution and kinetics of Gd within different healthy and cancerous tissues. © 2001 American Institute of Physics. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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