| Autor: |
Elsner, H.-A., O'Brien, B.J., Bryan, C.F., Meyer, J.A., Diederich, D.A., Pierce, G.E., Lau, M., Terasaki, P.I., Blasczyk, R. |
| Předmět: |
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| Zdroj: |
Tissue Antigens; Aug2000, Vol. 56 Issue 2, p180, 4p, 3 Diagrams, 1 Chart |
| Abstrakt: |
We have defined the new allele HLA-B*4012, which had been isolated from a black individual. It was initially recognized as a serologically unique allele when typing her father for renal transplantation. The HLA class I phenotype was A*0201,*6602; B*4001,*4012; Bw6; Cw*0304,*1505. Sequencing from exon 1 through intron 3 of B*4012 was performed. B*4012 is identical to B*4001 and B*4010 in exon 3, and in the 3´ part of exon 2, but it is unique in that exon 1 and the 5´ part of exon 2 are identical to B*1503, B*1509, B*1510, B*1518, B*1523, and B*1529. The generation of this allele is best explained by a recombination event in exon 2 (break point between nucleotides 205 and 222 from the beginning of the coding region) of B*4001 or B*4010 with one of these B*15 variants as a donor allele. Its unique serological feature (B48, B60, B70, and B72 reactivity) is consistent with the sequence data of its donor alleles. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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