| Autor: |
Agarwal, Shipra, Iyer, Venkateswaran, Agarwala, Sandeep, Mathur, Sandeep, Aron, Manju, Datta Gupta, S., Verma, Kusum, Iyer, Venkateswaran K, Mathur, Sandeep R |
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| Zdroj: |
Pediatric Surgery International; Mar2011, Vol. 27 Issue 3, p303-308, 6p, 1 Color Photograph, 2 Charts, 2 Graphs |
| Abstrakt: |
Purpose: Outcome for patients with Wilms tumor (WT) with favorable histology is good. Deletions of chromosomes 1p and 16q impart a poorer outcome. Value of apoptotic protein expression is not clear.Methods: Expression of four immunohistochemically detectable apoptosis-regulating proteins (bcl-2, bcl-x, bax and p53) were analyzed in 30 specimens of WT and compared to recurrence and recurrence-free survival (RFS).Results: The 30 patients included ranged from 4 to 72 months in age (mean 31). The mean available follow-up was 35.3 months (range 1-54). Six patients developed recurrence. The 5-year RFS for blastema-predominant tumors was 40% as compared to 91% for triphasic histology which was significant (p = 0.048). The 5-year RFS in patients with bcl-2 negative tumors was 63% as compared to 100% for bcl-2 positive tumors, the difference being significant (p = 0.019). The 5-year RFS in patients with p-53 positive tumors was 27% as compared to 91% for p-53 negative tumors; however, this difference in the RFS was not statistically significant (p = 0.143). bax and bcl-x expression were not related to the RFS.Conclusions: Tumors that are bcl-2 negative have a relatively higher recurrence rate and a poorer RFS. They may benefit from a more intensive follow-up regime for early detection of recurrence. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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