| Autor: |
Pozzilli, Paolo, Manfrini, Silvia, Monetini, Laura |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Clinical & Laboratory Investigation; Nov2001 Supplement 235, Vol. 61 Issue 7, p38-44, 7p |
| Abstrakt: |
In type 1 diabetes, a number of specific and non-specific antigens have been identified. The major autoantigens involved in the destructive process of cells leading to the development of type 1 diabetes are proinsulin/insulin, glutamic acid decarboxylase (GAD) and the transmembrane protein tyrosine phosphatase (IA-2). These are the only autoantigens that partially satisfy the criteria by which an autoantigen or cross-reactive nonself antigen could be evaluated for a pathogenic role in autoimmune diseases. Antigens by definition induce antibody production and in type 1 diabetes, such (auto) antibodies are accepted as biochemical markers for the disease. Here we describe the main features and usefulness of these markers for disease prediction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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