| Autor: |
Ishikawa, Yasunobu, Nishio, Saori, Sasaki, Hiroaki, Kudo, Risshi, Goto, Hideki, Ito, Masanori, Suzuki, Akira, Fukazawa, Yuichiro, Mochizuki, Toshio, Koike, Takao |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Nephrology; Feb2011, Vol. 15 Issue 1, p179-183, 5p |
| Abstrakt: |
Transplantation-associated thrombotic microangiopathy (TA-TMA) is a rare but devastating syndrome that occurs in allogeneic hematopoietic stem cell transplant recipients, and is associated with a variety of transplantation-related factors, including conditioning regimens, immunosuppressive agents, graft-versus-host disease (GVHD) and opportunistic infections. TA-TMA has an unfavorable prognosis and responds poorly to conventional treatment including plasma exchange (PE). We present a case of a 37-year-old man with membranous nephropathy (MN) and polyserositis caused by GVHD after hematopoietic stem cell transplantation. He developed TA-TMA after steroid pulse therapy for polyserositis. We treated the patient with PE and mycophenolate mofetil (MMF) after which the TA-TMA successfully improved and the MN underwent complete remission. The present case suggests that corticosteroids with severe GVHD might increase the risk of TA-TMA, and that PE in combination with MMF may be a valuable therapy to improve the prognosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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