The role of scintimammography with 99mTc-sestamibi as a complementary diagnostic technique in the detection of breast cancer.

Autor:	Danielsson, R., Reihnér, E., Grabowska, A., Boné, B., Reihnér, E, Boné, B
Předmět:	MAMMOGRAMS CANCER patients ADENOCARCINOMA BREAST cancer FIBROCYSTIC breast disease BREAST tumors COMPARATIVE studies DIFFERENTIAL diagnosis DIAGNOSTIC errors LONGITUDINAL method RESEARCH methodology MEDICAL cooperation NEEDLE biopsy ORGANIC compounds PHYSICAL diagnosis RADIONUCLIDE imaging RADIOPHARMACEUTICALS RESEARCH EVALUATION research CARCINOMA in situ DUCTAL carcinoma
Zdroj:	Acta Radiologica; Sep2000, Vol. 41 Issue 5, p441-445, 5p
Abstrakt:	Purpose: To prospectively determine the clinical value of scintimammography (Sc) with 99mTc-sestamibi as a complementary method to triple diagnosis (TD) in detecting malignant disease of the breast.Material and Methods: Ninety-six patients with 119 clinically or mammographically detected breast lesions underwent TD procedures, including clinical examination, mammography and fine-needle aspiration cytology. Prone planar Sc with 99mTc-sestamibi was performed in all 96 patients. Five groups were defined for diagnosis: 1=normal; 2=benign; 3=probably benign; 4=highly suspect of malignancy; and 5=malignant. All lesions were histopathologically examined. The results of each method per se and the combination of TD with Sc (TD+Sc) were analyzed.Results: Histopathology of the 119 surgically excised breast lesions found 83 malignant and 36 benign lesions. TD missed 6 of 83 carcinomas, resulting in a sensitivity of 92.7%. Sc alone showed sensitivity of 85.5%. The combination TD+Sc missed 1 of 83 carcinomas, and thus had a sensitivity of 98.7%. In mammographically dense breasts both TD and Sc detected 16 of 18 carcinomas, while the combination TD+Sc led to detection of all 18 carcinomas.Conclusion: Adding Sc to TD increases the sensitivity for detection of breast carcinomas. Sc with 99mTc-sestamibi is recommended as a complimentary method to TD in selected cases such as mammographically dense breasts. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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