Antiproliferative Diterpenoids from the Leaves of Isodon rubescens.
| Autor: | Xue-Mei Gao, Xiao Luo, Jian-Xin Pu, Ying-Li Wu, Yong Zhao, Li Bin Yang, Fei He, Xiao Nian Li, Wei-Lie Xiao, Guo-Qiang Chen, Han-Dong Sun |
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| Předmět: |
DITERPENES
LAMIACEAE BOTANICAL chemistry SPECTRUM analysis TUMORS BOTANICAL specimens ANTINEOPLASTIC agents MOLECULAR structure FOLIAR diagnosis BIOLOGICAL assay CELL lines COLORIMETRY HIGH performance liquid chromatography MEDICINAL plants NUCLEAR magnetic resonance spectroscopy RESEARCH funding STATISTICS TERPENES TOXICITY testing PHYTOCHEMICALS DATA analysis QUANTITATIVE research |
| Zdroj: | Planta Medica; Jan2011, Vol. 77 Issue 1, p169-174, 6p |
| Abstrakt: | A phytochemical study of Isodon rubescens leaves led to the isolation of five new diterpenoids, isorubesins A-E (1-5), and fifteen known diterpenoids. The structures of these new compounds were elucidated by spectroscopic evidence. Most of the diterpenoids were tested for cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human tumor cells. Some of them showed potent inhibitory activity. Compound 5 is the first reported atisane-type diterpenoid from this plant. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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