| Autor: |
Srirangarajan, S., Mundargi, Raghavendra C., Ravindra, S., Setty, Swati B., Aminabhavi, T. M., Thakur, Srinath |
| Předmět: |
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| Zdroj: |
Journal of Periodontology; Jan2011, Vol. 82 Issue 1, p114-121, 8p, 3 Diagrams, 2 Charts, 1 Graph |
| Abstrakt: |
Background: The aim of this randomized, split-mouth, single-masked study is to compare the efficacy of a gel and microspheres as drug-delivery systems in the treatment of periodontal disease. Methods: Microspheres were prepared, the release patterns of the microspheres and gel formulations were analyzed using an ultraviolet spectrophotometer, and particle shapes were studied under a scanning electron microscope. A split-mouth design was followed in which 30 potential sites were identified and divided into three groups: one control group and two groups in which microspheres or a gel was placed. Patients were recalled at 1,3, 6, and 9 months. Clinical recordings included plaque index (PI), gingival index (GI), probing depth (PD), and relative attachment level (RAL) measurements; subgingival plaque was also obtained for microbiologic examination prior to and after therapy. Results: Microspheres had a more sustained release and a high initial drug concentration. There was a significant improvement in the PI and GI in the initial 3 months. The results were statistically significant at P= 0.01. The mean PD scores among scores for the three groups at baseline and follow-up visits showed a reduction of 0.4 to 1 mm. The microbiologic parameters were also statistically significant. Conclusion: These data suggest that the type of delivery system could significantly influence the outcome of therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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