| Autor: |
Guldner, Norbert W, Klapproth, Peter, Margaritoff, Petra RJ, Noel, Ralf, Sievers, Hans H, Grossherr, Martin |
| Zdroj: |
Asian Cardiovascular & Thoracic Annals; 12/01/2009, Vol. 17 Issue 6, p592-597, 6p |
| Abstrakt: |
Experimental valveless muscular blood pumps (biomechanical hearts) in goats can pump more than 1 L·min -1, but due to a high pendulum volume, no significant flow contribution to the circulation is gained. Thus valved and valveless biomechanical hearts were compared for efficacy. Heart failure was induced in 5 adult Bore goats by repeated intracoronary embolization. A valved and balloon-equipped pumping chamber was integrated into the descending aorta, simulating standard biomechanical circulatory support. The valveless biomechanical heart supported a failing heart with a baseline cardiac output of 2,670 ± 710 mL·min -1 by contributing additional flow of 113 ± 37 mL·min -1. The biomechanical heart model incorporating an outlet valve offered an additional 304 ± 126 mL·min-1, and the use of 2 valves significantly enhanced pulmonary blood flow by 1,235 ± 526 mL·min-1. The use of 2 valves in biomechanical hearts seems to be essential to achieve adequate circulatory support. Double-valved biomechanical hearts driven by an appropriate skeletal muscle ventricle may contribute to the therapy of heart failure. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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