| Autor: |
Kuruvilla, K., Kenny, A. M., Raisz, L. G., Kerstetter, J. E., Feinn, R. S., Rajan, T. V. |
| Předmět: |
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| Zdroj: |
Osteoporosis International; Jan2011, Vol. 22 Issue 1, p217-221, 5p, 1 Chart, 3 Graphs |
| Abstrakt: |
Summary: We evaluated the effect of BMD on fracture risk prediction using FRAX® among Asian Indian men when used in conjunction with clinical risk factors. A majority of our subjects were either osteopenic or osteoporotic, and their fracture risk increased when FRAX® was used in conjunction with femur neck T-scores. Introduction: Asian Indian men living in the United States may represent a population that is at high and underappreciated risk for fragility bone fractures. Purpose: To evaluate the effect of BMD on fracture risk prediction using FRAX® among Asian Indian men when used in conjunction with clinical risk factors. Methods: Forty four Asian Indian men (mean age 64.9 (±8.4) years) who had lived in the United States for an average of 33.6 (±10.6) years underwent BMD measurement at the proximal femur. Subjects were subjected to a general physical exam and history of fracture, hip fracture in a parent, current smoking and alcohol use, and diagnosis of inflammatory arthritis was obtained. Data from each subject were entered into the FRAX® algorithm and 10-year fracture probabilities were calculated using clinical risk factors (CRFs) alone and in combination with femur neck T-scores. Results: Thirteen subjects (29.5%) had femur neck T-scores ≥ −1.0, 28 (63.6%) T-scores between −1.0 and −2.5, and three (6.8%) T-scores < −2.5. The 10-year probability of a major osteoporotic fracture based on a combination of clinical risk factors and femur neck T-scores was significantly higher than the fracture probability based on clinical risk factors alone ( t(43) = 2.58, p = 0.01). Conclusions: Among Asian Indian men, the 10-year probability of a major osteoporotic fracture increases when femur neck T-scores are added to clinical risk factors in the FRAX® algorithm, and this population have a high fracture probability even in the absence of clinical risk factors. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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