| Autor: |
Raoult, D., Gallias, H., Casanova, P., Bedjaoui, A., Akbaraly, R., Auzerie, J. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Jan1985, Vol. 15 Issue 1, p123-125, 3p |
| Abstrakt: |
We have used high performance liquid chromatography to evaluate the meningeal penetration of apalcillin. In subjects without meningitis the penetration was poor and the levels obtained did not exceed 1.75 mg/l. In cases of meningitis, when the spinal fluid albumin level was greater than 0.60 g/l, the levels varied from 5 to 30 mg/l. These figures are in accord with those obtained in cases of experimental meningitis. A dosage of 200 mg/kg/day should allow the treatment of meningitis due to sensitive bacteria and in particular due to Pseudomonas aeruginosa. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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