| Autor: |
Rolston, Kenneth, Bolivar, Ricardo, Fainstein, Victor, Jones, Paula, Elting, linda, Bodey, Gerald P., Rolston, K, Bolivar, R, Fainstein, V, Jones, P, Elting, L, Bodey, G P |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Jan1985, Vol. 15 Issue 1, p91-96, 6p |
| Abstrakt: |
Seventy-eight infectious episodes in 75 cancer patients with adequate granulocyte counts were treated with cefotaxime. Sixty-six episodes were evaluable. The overall cure rate was 77% (51/66). The response rate in 46 episodes where an organism was identified was 72% (33/46). Gram-positive and Gram-negative infections responded equally with rates of 81% and 80% respectively. Pneumonia, septicaemia and urinary ract infections occurred most frequently and had response rates of 62% (18/29), 90% (9/10) and 91% (10/11) respectively. Polymicrobial infections were associated with a poor response—40% (4/10). No serious adverse effects occurred. Cefotaxime as a single agent was effective therapy for most Gram-positive and Gram-negative infections n cancer patients with adequate granulocyte counts. Polymicrobial infections and Gram-negative pneumonias might require additional agents. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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