| Autor: |
Josefsson, Kenneth, Nord, Carl Erik, Josefsson, K, Nord, C E |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Oct1982, Vol. 10 Issue 4, p325-333, 9p |
| Abstrakt: |
Phenoxymethylpenicillin and erythromycin base were given orally in repeated doses to 16 healthy volunteers in two studies. A 2 g dose of penicillin was given followed by eight doses of 0·8 g, administered 6-hourly to eight subjects. A 0·5 g dose of erythromycin was given followed by six doses of 0·5 g, given 8-hourly to eight other volunteers. Saliva and blood samples were taken for 7 and 8 days, respectively, for cultivation of aerobic and anaerobic bacteria. With penicillin a significant decrease of, , fusobacteria and leptotrichia was found and with erythromycin a significant decrease and micrococci was found. No increased resistance to penicillin or erythromycin was found among the bacterial strains isolated. No toxin-producing clostridial strains were found. These doses seem to be acceptable from the point of view of the oral ecology. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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