| Autor: |
Peterson, Lance R., Gerding, Dale N., Fasching, Claudine E., Peterson, L R, Gerding, D N, Fasching, C E |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Jan1981, Vol. 7 Issue 1, p71-79, 9p |
| Abstrakt: |
A study on the importance of the route of antibiotic administration on achievable extravascular fluid drug concentration was performed in a rabbit model. Cefazolin was given either by repeated intramuscular injection or by constant intravenous infusion for 12 to 26 h. Cefazolin penetration into a high and low protein extravascular space was measured by sampling subcutaneous Visking chambers filled with serum or saline. Application of pharmacokinetic principles to equilibrium conditions allowed accurate prediction of the extravascular fluid concentrations. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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