| Autor: |
O'Connor, T. P., Roebuck, B. D., Peterson, F. J., Lokesh, B., Kinsella, J. E., Campbell, T. C. |
| Zdroj: |
JNCI: Journal of the National Cancer Institute; 6/2/1989, Vol. 81 Issue 11, p858-863, 6p |
| Abstrakt: |
We examined the effect of varying the ratio of dietary omega-3 (ω3) to omega-6 (ω6) on the development of pancreatic preneoplastic lesions in male Wistar rats given azaserine at 14 days of age. As the ratio of dietary ω 3 to ω 6 fatty acids increased in a diet totaling 20% by weight of fat, the development of preneoplastic atypical acinar cell nodules (AACNs) at 4 months after dosing with azaserine decreased significantly. In addition, serum levels of prostaglandin thromboxane B, prostaglandin E, and 6-keto-prostaglandin F decreased significantly. The fatty acid composition of the rbc membrane was also significantly influenced by the ratio of dietary ω 3 to ω 6 fatty acids. In a second experiment, we examined the effect of dietary intervention with a different type of fat (corn oil or menhaden oil) 2 months into the 4-month postdosing period on AACN development at the end of the post-dosing period. Intervention of the ω 6 fatty acid-rich diet with the ω 3 fatty acid-rich diet significantly decreased focal development. The opposite was true when intervention involved substituting the ω 3 fatty acid-rich diet with the ω6 fatty acid-rich diet. [J Natl Cancer Inst 81:858–863, 1989] [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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