| Autor: |
Fujita, Kenji, Miki, Nobuhiko, Mojica, Mariluz P., Takao, Shintaro, Phuchareon, Janyaporn, Nishikawa, Shin-ichi, Sudo, Tetsuo, Tokuhisa, Takeshi |
| Zdroj: |
International Immunology; Feb1993, Vol. 5 Issue 2, p227-230, 4p |
| Abstrakt: |
c- and c- gene products form a heterodimeric complex (AP-1) that regulates target gene expression by binding to a specific DNA sequence motif. In order to study a role of AP-1 (Fos/Jun) in growth and differentiation of immature B lineage cells, we have established and mated two independent transgenic mice carrying the mouse c- gene or the viral v- gene fused to the H-2K promoter. IL-7 dependent bone marrow cell culture from doubly transgenic (H2-) mice demonstrated severe delay of early B cell development. Proliferation of pre-B cells in the fresh bone marrow from HZ- mice to IL-7 stimulation was very low. These results suggest that the deregulated production of AP-1 perturbs IL-7 mediated proliferation and differentiation of immature B cells. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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