| Autor: |
Napalkov, N., Likhachev, A., Anisimov, V., Lokitonov, A., Zabezhinski, M., Ovsyannikov, A., Wahrendorf, J., Becher, H., Tomatis, L. |
| Zdroj: |
Carcinogenesis; 1987, Vol. 8 Issue 3, p381-385, 5p |
| Abstrakt: |
Pregnant SHR mice were treated once with 7,12-dimethyl-benz[a]anthracene (DMBA) on day 17–19 of gestation, and F and F descendants received multiple skin applications of 12--tetradecanoylphorbol-13-acetate (TPA) twice a week for 24 weeks beginning at 12 weeks of age. Post-natal promoter treatment resulted in a high incidence of skin twmours in F and F mice (37.3 and 19.7%, respectively), whereas only 6.6% of control animals treated with TPA only developed skin tumours. DMBA was shown previously to be capable of in itiating skin carcinogenesis transplacentally; however, our results on the second generation provide suggestive evidence of hereditary transmission of at least part of the initiating action of this carcinogen. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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