| Autor: |
Lindenschmidt, R.C., Margaretten, N., Griesemer, R.A., Witschi, H.P. |
| Zdroj: |
Carcinogenesis; 1986, Vol. 7 Issue 9, p1581-1586, 6p |
| Abstrakt: |
The effects of hyperoxia on lung tumor development were examined in mice and rats. In mice, exposure to 70% Oprevented the development of urethan- or 3-methykholan-threne-induced lung tumors. Dietary antioxidants [butylated hydroxytoluene (BHT) and butylated hydroxyanisote (BHA)] were unable to prevent the inhibition of tumor development by oxygen, although BHT retained its capability to enhance tumor development in mouse lung. In visible-size tumors, oxygen did not depress DNA synthesis. Oxygen also reduced the number of pulmonary metastatk nodules after i.v. injection of mammary gland-derived carcinoma cells, but failed to inhibit growth of murine lung carcinoma or murine melanoma-derived cell lines. Rats treated with one single intratracheal instillation of 3-methylcholanthrene developed multiple lung lesions; their growth could be prevented by exposure of the animals to 40 or 70% O. It is concluded that hyperoxia prevents development of transformed cells in the lung and may affect adversely the growth of selected cell lines meta-static to the lung. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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