| Autor: |
Ribeiro, Odartey, Kirkby, Charles A., Hirom, Paul C., Millburn, Peter |
| Zdroj: |
Carcinogenesis; 1986, Vol. 7 Issue 3, p481-484, 4p |
| Abstrakt: |
3-Hydroxybenzo[a]pyrene (3-OH-BaP) is oxidized by the horseradish peroxidase/HO system to benzo[a]pyrene-3, 6-quinone. In the presence of N-acetylcysteine one other product is also formed. This was identified by its chemical, and u.v., mass and n.m.r. spectral properties as 6-(-acetylcystein-S-yl)-3-hydroxybenzo[a]pyrene (6-NAc-cys-3-OH-BaP). Replacement of the -acetylcysteine by glutathione leads to the formation of a 3-OH-BaP -glutathione adduct. Enzymic hydrolysis of benzo[a]pyrene-3-glucuronide in the presence of -acetykysteine yields, in addition to 3-OH-BaP, a product which co-chromatographs with 6-NAc-cys-3-OH-BaP and has identical chemical and spectral characteristics. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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