| Abstrakt: |
Teratologic Evaluation of Orally Administered Nitrapynn in Rats and Rabbits.BERDASCO, 2N.M., LOMAX, L.G., ZIMMER, M. A., AND HANLEY, T. R., JR. (1988). 11, 464—471. Pregnant Fischer 344 rats and New Zealand White rabbits were orally administered 0, 5, 15, or 50 mg nitrapyrin/kg/day on Gestation Days 6 through 15 (rats) or 0, 3, 10, or 30 mg/kg/day on Gestation Days 6 through 18 (rabbits). In rats, 50 mg/kg/day produced slight histopathologic changes in the livers of pregnant females. Fetal examination revealed no evidence of fetotoxicity or teratogenicity among rats at dose levels up to 50 mg/kg/day. Among rabbits, a significant depression in maternal weight gain and increased absolute and relative liver weights were observed at 30 mg/kg/day. An increased incidence of crooked hyoid bone among fetal rabbits in the 30 mg/kg/day dose group was considered indicative of fetotoxicity but not 3 teratogenicity. Thus, administration of nitrapyrin was not teratogenic at dose levels up to 50 mg/kg/day in rats and 30 mg/kg/day in rabbits [ABSTRACT FROM PUBLISHER] |
