| Abstrakt: |
Effects of ClO on the Absorption and Distribution of Dietary Iodide in the Rat HARRINGTON, R. M., SHERTZER, H. G., AND BERCZ, J. P. (1985). . 5, 672–678. Aqueous chlorine dioxide (ClOg), an alternative disinfectant for drinking water, was found to decrease gastrointestinal (GI) bioavailability of dietary iodide. It has been previously reported that subchronic exposure to ClO decreases thyroxine (T) levels in nonhuman primates. In this study experiments with animal feed, isolated rat stomachs, as well as studies with intact rats, showed that ClO in drinking water (at concentrations as low as 2 ppm) oxidizes iodide to its reactive elemental (radical) state, binding it to organic substances present in the GI tract. A single instance of acute exposure to ClO, however, did not decrease blood iodide levels, or thyroid glandular uptake of iodine [ABSTRACT FROM PUBLISHER] |
