| Abstrakt: |
Pharmacokinetics of Inhaled Methyl Chloride (CHCl) in Male Volunteers. Nolan, R. J., RICK, D. L., LANDRY, T. D., MCCARTY, L. P., AGIN, G. L., and SAUNDERS, J. H. (1985). Fundam. Appl. Toxicol. 5, 361–369. Six volunteers, 25–41 years of age, were exposed for 6 hr on separate days to 50 and 10 ppm of CHCl. Blood and expired air CHCl concentrations reached an apparent plateau during the first hour of the exposure and were proportional to the exposure concentration. Consistent with previous reports, the volunteers could be separated into two discrete groups based on the differences observed in their blood and expired air CHCl concentrations. Both groups eliminated CHCl rapidly once the exposure was terminated, but CHCl was eliminated more rapidly by those volunteers with the lower blood and expired air CHCl concentrations. The existence of these two groups can be explained by a twofold difference in the rate at which they metabolized CHCl; however, this difference is of questionable toxicological significance. Urinary excretion of the putative metabolite -methyl cysteine was not related to the exposure; thus, it is not a valid means of monitoring occupational exposure to CHCl. [ABSTRACT FROM PUBLISHER] |
