| Autor: |
Tuitoek, P. J., Ziari, S., Tsin, A. T. C., Rajotte, R. V., Suh, Miyoung, Basu*, Tapan K. |
| Zdroj: |
British Journal of Nutrition; Apr1996, Vol. 75 Issue 4, p615-622, 8p |
| Abstrakt: |
Using streptozotocin-induced diabetic Wistar rats, studies were carried out to examine the metabolic availability of vitamin A in the plasma, liver and the retina of the eye. Control and diabetic rats were fed ad lib. on a semi-purified diet either with or without (basal) vitamin A supplementation, or pair-fed on the basal diet for 4 weeks. Despite the fact that diabeticrats consumed 48% more feed, they had lower plasma concentrations of retinol (P<0·003). The decrease in plasma retinol concentration was a response to diabetes (or diabetes-induced trauma), since neither pair-feeding (P<0·01) nor vitamin A supplementation altered this effect (P<0·05). Furthermore, the hepatic concentrations of the vitamin in these animals remained elevated and this increase was greater in the supplemented diabetic group (P<0·001). Decreases in 11-cis retinal (a component of rhodopsin) concentrations in the retina were also observed in diabetic animals. The increased hepatic and the decreased plasma and retina vitamin Alevels suggest a defect in the transport of the vitamin from the liver. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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