Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose???response study in healthy females.

Autor: Kemi, Virpi E., K??rkk??inen, Merja U. M., Karp, Heini J., Laitinen, Kalevi A. E., Lamberg-Allardt, Christel J. E.
Zdroj: British Journal of Nutrition; Apr2008, Vol. 99 Issue 4, p832-839, 8p
Abstrakt: A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose???response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21???40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200??mg, and each subject served as her own control. The meals on each study day provided 1850??mg P and 480??mg Ca. S-PTH concentration decreased (P??
Databáze: Complementary Index
načítá se...