| Autor: |
Davydova, S. M., Cheido, M. A., Gevorgyan, M. M., Idova, G. V. |
| Zdroj: |
Bulletin of Experimental Biology & Medicine; Aug2010, Vol. 150 Issue 2, p219-221, 3p |
| Abstrakt: |
Experiments on CBA mice showed that selective stimulation of 2A serotonin receptors with DOI agonist (1 mg/kg) led to suppression of the immune response and reduction of the spleen and peripheral blood CD8 T cell counts with the cytotoxic/suppressor function. Selective blockade of these receptors with ketanserin (1 mg/kg) had an opposite effect: immunostimulation with an increase in CD8 T cell count in the spleen. These data indicate the involvement of 2A serotonin receptors in immunosuppressive mechanisms of serotoninergic system. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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