| Autor: |
MEBUS, C. A., CARPANINI, F. M. B., RICKARD, R. W., CASCIERI, T. C., TYLER, T. R., VINEGAR, M. B. |
| Zdroj: |
Fundamental & Applied Toxicology; Feb1995, Vol. 24 Issue 2, p206-216, 11p |
| Abstrakt: |
Vinyl acetate (VA) is a commonly used chemical in polymerization and copolymerization processes and as a chemical intermediate. As part of a collaborative effort between VA producers of the United States and British Petroleum, the present study was carried out to provide a base set of data for risk assessment. Groups of male and female Crl:CD(SD)BR rats were given 0, 200, 1000, or 5000 ppm VA via the drinking water over two generations. In addition, a cross-mating trial of control and 5000-ppm male and female rats was conducted in the F generation to investigate the slightly decreased litter production in the high-dose group. No treatment-related mortality was observed in any of the groups. Water consumption was significantly reduced in the 5000-ppm groups in both generations and in the 1000-ppm F, female rats. The body weights of the F and F male rats and the F, female rats in the 5000-ppm group tended to be slightly lower than those of the control group. Body weight gain was significantly decreased during lactation in the F females at 5000 ppm and in the F, females at 1000 and 5000 ppm. Pup weights in the F, generation, but not in the F generation, were significantly lower than those of the control on lactation Day 21. The number of litters produced in the F generation in the 5000-ppm group was slightly lower than that of the control group and was attributed to lower fertility. Fewer pups were produced when control females were mated with the 5000-ppm males; however, the decrease was due to poor mating performance rather than decreased fertility. No decrease was apparent when the 5000-ppm females were mated with the control group males. Under the conditions of this study, the no-observed adverse effort level was considered to be 1000 ppm. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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