| Abstrakt: |
Interactions of Water Contaminants. I. Plasma Enzyme Activity and Response Surface Methodology following Gavage Administration of CCl and CHCl or TCE Singly and in Combination in the Rat. BORZELLECA, J. F., O'HARA, T. M., GENNINGS, C, GRANGER, R. H., SHEPPARD, M. A., AND CONDIE, L. W., JR. (1990). . , 477–190. The joint hepatotoxicity of CCU and CHC13 or TCE in male CD rats following simultaneous oral administration has been investigated. Rats with chronic indwelling arterial cannulas were administered a single oral dose of COl, and CHCl or CCl and TCE in 5% Emulphor at doses of 0 to 700 mg/kg. Hepatotoxicity was evaluated by measuring the activity of AST, ALT, and SDH in plasma at 0, 3, 6, 12, 24, 36, 48, and 72 hr postgavage. Response data were analyzed for interaction using response surface methodology. CCl alone displayed dose-dependent toxicity. TCE demonstrated little evidence of hepatotoxicity. In combination, both CCl/CHCl and CCl/TCE displayed a synergistic (supraadditive) response for peak plasma enzyme activity. [ABSTRACT FROM PUBLISHER] |
