| Abstrakt: |
Disposition and Elimination of Three Polychlorinated Dibenzofurans in the Liver of the Rat. VAN DEN BERG, M., DE JONGH, J., ECKHART, P., AND VAN DER WIELEN, F. W. M. (1989). . , 738–747. The disposition and elimination of 1,2,3,6,7,8-HxCDF (HxCDF), 1,2,3,7,8-PnCDF (1-PnCDF), and 2,3,4,7,8-PnCDF (4-PnCDF) were studied in liver of female Sprague-Dawley rats after administration of a single oral dose of 3.5–6.3 μg/kg. The disposition of these PCDF congeners was structure and vehicle dependent. Administration in peanut oil caused the highest liver retention, compared with administration through the standard diet. Half-lives in liver for 1-PnCDF, 4-PnCDF, and HxCDF were 3.3, 108, and 73 days, respectively. 4-PnCDF showed very high liver retention: ≥70% of the dose in the first days after administration. To study kinetic interaction in the liver, mixtures of 1-PnCDF and 4-PnCDF (Experiment I) and of 4-PnCDF and HxCDF (Experiment II) were administered. The presence of 4-PnCDF in Experiment I did not significantly influence the half-life of I-PnCDF. In Experiment II the estimated half-life of 4-PnCDF was again 108 days, but for HxCDF an increased half-life was found, 156 days. It is concluded that PCDFs with a chlorine substituent(s) adjacent to the oxygen bridge (4- and 6-positions) are eliminated vcry slowly with 14 much greater than that of TCDD. [ABSTRACT FROM PUBLISHER] |
