| Abstrakt: |
Distribution and Elimination of the Stereoisomers of Soman and Their Effect on Brain Acetylcholine. NORDGREN, I., LUNDGREN, G., PUU, G., KARLÉN, B., AND HOLMSTEDT, B. (1985). . 5, S252–S259. The four stereoisomers of soman (O-( 1,2,2-trimethylpropyl)-methyl-fluorophosphonate) have been analyzed in mouse blood and tissues after administration of doses corresponding to 0.75 × LD50 of the two diastereoisomeric pairs of soman (S-and R-soman). The disappearance of the four isomers has been studied in the presence of enzymes involved in the toxicity and detoxification of soman, e.g., acetyl- and pseudocholin-esterase, aliesterase, and phosphorylphosphatase. The effect of S- and R-soman on brain acetylcholine was studied in the mouse. The analytical methods used are based on gas chromatography-mass spectrometry with deuterated internal standards. RR- and SR-soman, the two isomers that preferentially react with acetylcholinesterase, were found in blood and liver. In liver the concentration of SR was higher than that of RR and could be followed for 18 hr. In blood only SR could be found. Its presence there could be followed during 18 hr. The levels were, however, lower than in liver. The results indicate that the liver might be a depot for soman and that SR might be responsible for the delayed intoxication noted after treatment with antidotes. R-soman was found to have a more pronounced effect on the acetylcholine synthesizing system than has S-soman, which might explain its higher toxicity. [ABSTRACT FROM PUBLISHER] |
