| Abstrakt: |
Chemical Urolithiasis 2. Thermodynamic Aspects of Bladder Stone Induction by Terephthalic Acid and Dimethyl Terephthalate in Weanling Fischer-344 Rats. Heck, H. d'A. (1981). 1:299–308. The induction of calcium terephthalate (CaTPA) calculi in the urinary tract of rats ingesting terephthalic acid (TPA) or dimethyl terephthalate is a result of supersaturation with respect to the stone components. The solubility product of CaTPA was determined in water at 37 °C, and its value in urine of exposed weanling Fischer-344 rats was calculated based on the electrolyte concentrations of freshly-collected, microliter urine samples. The value of the solubility product in urine is equal to the minimum concentration product of free Ca and TPA at which crystallization can occur; hence, the urinary solubility product is a parameter that is useful for risk assessment. Estimates of the TPA concentrations required to induce crystals or stones in normal human urine are presented. [ABSTRACT FROM PUBLISHER] |
