| Autor: |
Brunkhorst, R., Brunkhorst, U., Eisenbach, G. M., Schedel, I., Deicher, H., Koch, K. M. |
| Zdroj: |
Nephrology Dialysis Transplantation; Feb1992, Vol. 7 Issue 2, p87-92, 6p |
| Abstrakt: |
Several authors described a high incidence of proteinuria with frequent progression to nephrotic syndrome and/or renal failure in patients with HIV infection. Though renal histological changes were rather non-specific, the existence of a specific, HIV-associated glomerulopathy was postulated. We repeatedly investigated proteinuria and serum creatinine in 203 HIV-infected patients. One hundred and twenty-two patients (group 1) had early stages of the disease without opportunistic infections, 81 suffered from acute opportunistic infections (group 2). In patients with a positive qualitative test (Combistix®), quantitative measurement (Biuret) for proteinuria was carried out; when proteinuria was >0.5g/24h, SDS gel electrophoresis was performed. None of the patients of group 1 had a proteinuria >0.5 g/24 h or an elevated serum creatinine. Eleven of 81 patients from group 2 had a proteinuria between 0.5 and 3 g/24 h; one further patient of group 2 developed a transient proteinuria of 7.7 g/24 h. Only three of the proteinuric patients showed a glomerular pattern in SDS gel electrophoresis, all three during acute CMV or EBV infections. Fourteen of 81 group 2 patients showed a transient elevation of serum creatinine (X±SD of the maximum serum creatinines: 225.3 ± 163 umol/1), most during pentamidine therapy for Pneumocystis carinii infection; one patient treated with high-dose acyclovir had to be temporarily dia-lysed. In the investigated 203 HIV patients no nephrotic syndrome and no sustained elevation of serum creatinine greater than 200 μmol/1 was observed. All cases of proteinuria and elevation of serum creatinine were associated with severe opportunistic infections and the administration of potentially nephrotoxic antibiotics. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
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